Wirth K, Schomerus M, Hengstmann J H
Infection. 1976;4(2):25-30. doi: 10.1007/BF01638344.
Azlocillin, a new semisynthetic penicillin with a wide spectrum of antimicrobial activity and a member of the ureidopenicillin group, was administered to ten adults in a dosage of 2 g by intravenous bolus injection. The determination of antibiotic activity in serum and urine demonstrated an average concentration of 58.9 mug/ml after one hour, 28.1 mug/ml after two hours and 6.1 mug/ml after four hours. The total urinary excretion was 60% within six hours. The pharmacokinetic parameters were calculated for the one and two compartment models, respectively. Mathematical analysis according to an open two-compartment model resulted in better curve adjustment as judged from the sum of the deviant squares. The resulting parameters for volume of distribution and rate of elimination show only minor differences however. Similar results were seen on comparison with the respective data for ampicillin.
阿洛西林是一种新型半合成青霉素，具有广泛的抗菌活性，属于脲基青霉素类。对10名成年人进行静脉推注，剂量为2克。血清和尿液中抗生素活性的测定表明，1小时后平均浓度为58.9微克/毫升，2小时后为28.1微克/毫升，4小时后为6.1微克/毫升。6小时内尿中总排泄量为60%。分别计算了单室和双室模型的药代动力学参数。根据开放双室模型进行的数学分析表明，从偏差平方和判断，曲线拟合效果更好。然而，分布容积和消除速率的结果参数仅显示出微小差异。与氨苄西林的相应数据相比，结果相似。
