Dose- and time-response relationships of triethylenemelamine-induced chromosomal aberrations in rat bone marrow cells.
作者信息
Levine B S, Pergament E, Driscoll K
出版信息
Toxicol Lett. 1982 Feb;10(2-3):281-5. doi: 10.1016/0378-4274(82)90088-1.
PMID:7080098
Abstract
Groups of 18 male Sprague-Dawley rats were administered single i.p. doses of 0.00, 0.125, 0.25 or 0.50 mg/kg of triethylenemelamine (TEM). 6 rats per treatment group were killed 6, 24 or 48 h after dosing, and bone marrow cells were collected and prepared for cytogenetic analysis. Under the present conditions, 0.25 mg/kg with sampling of bone marrow cells 24 h after treatment appeared to represent optimal conditions for using TEM as a positive control agent in the rat in vivo cytogenetic assay as described.
摘要
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