Levine B S, Pergament E, Driscoll K
Toxicol Lett. 1982 Feb;10(2-3):281-5. doi: 10.1016/0378-4274(82)90088-1.
Groups of 18 male Sprague-Dawley rats were administered single i.p. doses of 0.00, 0.125, 0.25 or 0.50 mg/kg of triethylenemelamine (TEM). 6 rats per treatment group were killed 6, 24 or 48 h after dosing, and bone marrow cells were collected and prepared for cytogenetic analysis. Under the present conditions, 0.25 mg/kg with sampling of bone marrow cells 24 h after treatment appeared to represent optimal conditions for using TEM as a positive control agent in the rat in vivo cytogenetic assay as described.
将18只雄性斯普拉格-道利大鼠分为几组，分别腹腔注射0.00、0.125、0.25或0.50mg/kg的三亚乙基三聚氰胺（TEM）。给药后6、24或48小时处死每个治疗组的6只大鼠，收集骨髓细胞并制备用于细胞遗传学分析。在目前的条件下，0.25mg/kg剂量并在治疗后24小时采集骨髓细胞，似乎是将TEM用作所述大鼠体内细胞遗传学试验阳性对照剂的最佳条件。
