Grosset J, Truffot C, Boval C
Tubercle. 1982 Mar;63(1):37-43. doi: 10.1016/s0041-3879(82)80007-x.
To determine whether or not low dosage prothionamide (PTH), with or without diamino diphenyl sulphone (DDS), can replace PAS or thiacetazone as the companion drug to isoniazid (INH) in the treatment of tuberculosis, two experiments have been performed in mice. In experiment I the 2-month effectiveness of 25mg/kg INH alone, INH+PTH (25mg/kg) or INH+PTH+DDS (10mg/kg) was investigated. Both PTH-containing regimens were equally effective in preventing the selection of INH-resistant mutants but PTH did not appear to add much to the bactericidal activity of INH. In experiment II the one year effectiveness of similar regimens supplemented by an initial month of streptomycin (SM) was investigated. Again PTH appeared very effective whereas DDS seemed ineffective. Therefore it seems that PTH is likely to be a good companion drug for INH when used in man at the dosage of 5mg/kg which is more or less equivalent to 25mg/kg in the mouse.
为了确定低剂量的丙硫异烟胺（PTH），无论是否联合氨苯砜（DDS），能否替代对氨基水杨酸（PAS）或硫醋腙作为异烟肼（INH）治疗结核病的联合用药，在小鼠身上进行了两项实验。在实验I中，研究了单独使用25mg/kg INH、INH + PTH（25mg/kg）或INH + PTH + DDS（10mg/kg）的2个月疗效。两种含PTH的治疗方案在防止INH耐药突变体的产生方面同样有效，但PTH似乎并未显著增强INH的杀菌活性。在实验II中，研究了类似方案补充初始1个月链霉素（SM）后的1年疗效。同样，PTH似乎非常有效，而DDS似乎无效。因此，当以5mg/kg的剂量用于人体时，PTH似乎可能是INH的良好联合用药，该剂量在小鼠中大致相当于25mg/kg。
