Urbanczik R
Chemotherapy. 1980;26(4):276-81. doi: 10.1159/000237917.
46 strains of Mycobacterium tuberculosis were studied as to their susceptibility to isoniazid (INH) or to INH + prothionamide (PTH) in the presence or absence of dapsone (DDS) by microdilution transfer plate technique. Synergy with DDS as defined by Berenbaum in 1978 was seen in 78% with INH and in 91% with INH + PTH. It concerned the minimal inhibitory concentration, whereas the minimal bactericidal concentration (MBC) was unaffected in the case of INH and it was increased in only 52% with INH + PTH. The latter MBC proportion mentioned would be decreased to roughly 16% accepting an only twofold decrease in the MBC as possibly due to dilution errors. The possible effect of dimethyl sulphoxide on the reported results is discussed.
采用微量稀释转移平板技术，对46株结核分枝杆菌在有无氨苯砜（DDS）的情况下对异烟肼（INH）或异烟肼+丙硫异烟胺（PTH）的敏感性进行了研究。1978年Berenbaum定义的与DDS的协同作用在78%使用INH的菌株和91%使用INH+PTH的菌株中可见。这涉及最小抑菌浓度，而异烟肼的最小杀菌浓度（MBC）不受影响，使用INH+PTH时仅有52%的菌株最小杀菌浓度增加。若仅将MBC降低两倍视为可能由稀释误差导致，那么上述提到的后一种MBC比例将降至约16%。文中讨论了二甲基亚砜对报告结果可能产生的影响。
