Mahrle G, Berger H
Z Hautkr. 1982 Mar 15;57(6):429-33.
Retinoids given in a high dosage are able to reduce or prevent the growth of experimental skin tumors in animals. Our study on the systemic effect of aromatic retinoid (Ro 10-9359) on DMBA-induced skin tumors in rabbits supported these findings. The antitumor effect seems to be independent of the type of tumor induction. Previous reports and the possibility of using this retinoid effect in the treatment of skin tumors in man are discussed.
高剂量给予的维甲酸能够减少或预防动物实验性皮肤肿瘤的生长。我们关于芳香维甲酸（Ro 10-9359）对兔二甲基苯并蒽诱导的皮肤肿瘤的全身作用的研究支持了这些发现。抗肿瘤作用似乎与肿瘤诱导类型无关。文中还讨论了先前的报道以及将这种维甲酸效应用于治疗人类皮肤肿瘤的可能性。
