Korzaia L I
Zh Mikrobiol Epidemiol Immunobiol. 1982 Mar(3):59-63.
The data obtained of the acute and chronic toxicity of a number of staphylococcal immune preparations are presented. The paw edema test has been shown to yield more informative results for the evaluation of acute toxicity than the method of intraperitoneal injection and LD50 determination. The paw edema test has revealed that the toxicity of corpuscular vaccine is higher than that of the preparations of water-soluble antigenic staphylococcal complexes. The chronic toxicity test has demonstrated that corpuscular vaccine, antiphagin, adsorbed toxoid and the antigenic complex have low toxicity: their multiple administration in doses exceeding the equivalent doses 30-200 times have been found to exert no influence on the increase of the weight of the animals.
本文给出了多种葡萄球菌免疫制剂的急慢性毒性实验数据。爪肿胀试验结果表明，相较于腹腔注射法和半数致死量测定法，该试验在评估急性毒性方面能提供更多信息。爪肿胀试验显示，颗粒疫苗的毒性高于水溶性葡萄球菌抗原复合物制剂。慢性毒性试验表明，颗粒疫苗、抗吞噬素、吸附类毒素和抗原复合物的毒性较低：发现以超过等效剂量30至200倍的剂量多次给药，对动物体重增加没有影响。
