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[接种钩端螺旋体病疫苗者体内抗体的性质]

[Nature of the antibodies in persons inoculated with a leptospirosis vaccine].

作者信息

Stoianova N A, Popova E M, Sergeĭko L M, Potachev A F

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1982 Apr(4):93-5.

PMID:7080768
Abstract

The results obtained in the study of the intensity and character of immunity in persons immunized with commercial leptospirosis vaccine are presented. These results indicate that antibody formation occurs only in 12.5% of the vaccinees; antibodies are not formed to all Leptospira strains contained in the vaccine, and in 6 months all antibodies completely disappear. In persons immunized with a single vaccine dose the agglutinating activity of blood sera was linked only with IgM. In persons subjected to multiple immunizations for a number of years IgG could also be detected. Cases of leptospirosis among vaccinees have been registered.

摘要

本文展示了对接种商业钩端螺旋体疫苗人群的免疫强度和特性研究结果。这些结果表明,仅12.5%的接种者产生抗体形成;并非对疫苗中所有钩端螺旋体菌株都产生抗体,且6个月后所有抗体完全消失。单剂量接种疫苗者血清的凝集活性仅与IgM有关。多年多次接种者也可检测到IgG。已记录到接种者中发生钩端螺旋体病的病例。

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