Kantorovich R A, Leshchinskaia E V, Martynenko I N, Volodina N I, Karazhas N V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1982;82(3):77-83.
The results of combined clinico-virological and immunological examinations of 25 children with rubellar meningoencephalitis are presented. The meningoencephalitis was preceded by typical rubella in 24, and by rubellar infection without eruptions in 1 child. In 6 children the rubella virus was isolated from the cerebrospinal fluid in the acute period of the disease (5th to 19th days), and in 2 children it was re-isolated on the acute period of the disease (5th to 19th days), and in 2 children it was re-isolated on the 17th-19th days. A persistence of the immunoglobulins M specific to the rubella virus was revealed both in the acute period of the disease and long time after the disease onset (the observation period was 409 days). The data obtained confirm the etiological role of the rubella virus in the development of rubellar meningoencephalitis, suggesting that the rubella virus may persist in complicated post-natal rubella.
本文展示了对25例风疹性脑膜脑炎患儿进行临床病毒学和免疫学联合检查的结果。24例患儿在患脑膜脑炎之前有典型风疹，1例患儿有风疹感染但无皮疹。6例患儿在疾病急性期（第5至19天）从脑脊液中分离出风疹病毒，2例患儿在疾病急性期（第5至19天）再次分离出风疹病毒，2例患儿在第17至19天再次分离出风疹病毒。在疾病急性期和发病后很长一段时间（观察期为409天）均发现了风疹病毒特异性免疫球蛋白M的持续存在。所获得的数据证实了风疹病毒在风疹性脑膜脑炎发病中的病因学作用，提示风疹病毒可能在产后风疹并发症中持续存在。
