Grubbauer H M, Borkenstein M, Wendler H
Klin Padiatr. 1978 Mar;190(2):125-8.
The paper reports on a case of "late onset disease" (congenital German measles). Diagnostically significant for this disease in an infant appearing perfectly healthy when new-born, were mainly the findings of an interstitial pneumonia, hepatosplenomegaly, as well as findings indicating the presence of a meningoencephalitis and retinopathy. The diagnosis of this rare course of congenital German measles was finally established via the identification of specific IgM rubeola antibodies, of a raised hemagglutination inhibition titer, and of the German measles virus itself. An attempt to treat the interstitial pneumonia with cortisone preparations remained unsuccessful. The clinical and diagnostic problem complexes are discussed briefly.
该论文报道了一例“迟发性疾病”（先天性风疹）病例。对于一名新生儿时看似完全健康的婴儿来说，这种疾病在诊断上具有重要意义的主要是间质性肺炎、肝脾肿大的表现，以及提示存在脑膜脑炎和视网膜病变的表现。通过鉴定特异性风疹IgM抗体、升高的血凝抑制效价以及风疹病毒本身，最终确诊了这种先天性风疹的罕见病程。尝试用皮质激素制剂治疗间质性肺炎未成功。文中简要讨论了临床和诊断方面的问题。
