Zsotér T T, Wolchinsky C
Arch Int Pharmacodyn Ther. 1978 Aug;234(2):287-93.
This study was undertaken to determine whether alterations in 45Ca kinetics, found previously in the aorta of spontaneously hypertensive rats (SHR), are the cause or the consequence of high blood pressure. SHR were treated for 3-6 weeks with hydralazine, propranolol or timolol before the uptake and efflux of 45Ca was measured in the aorta and compared with those in untreated animals. Hydralazine prevented the development of hypertension in the rats but did not alter the uptake or efflux of 45Ca. It is concluded that calcium handling in SHR is abnormal also in the absence of high arterial pressure.
本研究旨在确定先前在自发性高血压大鼠（SHR）主动脉中发现的45Ca动力学改变是高血压的原因还是结果。在用肼屈嗪、普萘洛尔或噻吗洛尔对SHR进行3至6周治疗后，测量主动脉中45Ca的摄取和流出，并与未治疗动物进行比较。肼屈嗪可预防大鼠高血压的发展，但不改变45Ca的摄取或流出。结论是，在没有高动脉压的情况下，SHR的钙处理也是异常的。
