Zsotér T T, Wolchinsky C, Henein N F, Ho L C
Cardiovasc Res. 1977 Jul;11(4):353-7. doi: 10.1093/cvr/11.4.353.
In the search for abnormalities in hypertensive vessels Ca kinetics was studied in the aorta of spontaneously hypertensive rats (SHR). The uptake of 45Ca was significantly less in hypertensive animals but the uptake of 'Lanthanum resistant' 45Ca was not. The efflux of 45Ca from aorta of SHR was different (P less than 0.01) from that of control rats because of faster initial efflux. The half-life of the first 2 components of efflux curves was significantly shorter in SHR. Results are interpreted as consequences of decreased Ca binding by smooth muscle membrane in hypertensive vessels.
在寻找高血压血管异常的过程中，对自发性高血压大鼠（SHR）主动脉的钙动力学进行了研究。高血压动物中45Ca的摄取显著减少，但“镧抗性”45Ca的摄取没有减少。由于初始流出更快，SHR主动脉中45Ca的流出与对照大鼠不同（P<0.01）。SHR中流出曲线前两个成分的半衰期显著缩短。结果被解释为高血压血管中平滑肌膜钙结合减少的后果。
