Taylor R L, Williams D M, Craven P C, Graybill J R, Drutz D J, Magee W E
Am Rev Respir Dis. 1982 May;125(5):610-1. doi: 10.1164/arrd.1982.125.5.610.
Incorporation of amphotericin B into liposomes significantly altered its toxicity, tissue distribution, and efficacy. Compared with intravenously administered amphotericin B-desoxycholate, liposome-amphotericin B showed a reduced acute toxicity and a maximal tolerable dose 9 times greater than amphotericin B-desoxycholate. Liposome-amphotericin B also produced higher tissue and lower serum concentrations than amphotericin B-desoxycholate, and was significantly more effective in prolonging survival of mice infected with Histoplasma capsulatum.
两性霉素B包封于脂质体中可显著改变其毒性、组织分布及疗效。与静脉注射两性霉素B-去氧胆酸盐相比，脂质体两性霉素B的急性毒性降低，最大耐受剂量比两性霉素B-去氧胆酸盐高9倍。脂质体两性霉素B在组织中的浓度也高于两性霉素B-去氧胆酸盐，而在血清中的浓度则较低，在延长荚膜组织胞浆菌感染小鼠的生存期方面显著更有效。
