Bakker-Woudenberg I A, Lokerse A F, ten Kate M T, Melissen P M, van Vianen W, van Etten E W
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, The Netherlands.
Eur J Clin Microbiol Infect Dis. 1993;12 Suppl 1:S61-7. doi: 10.1007/BF02389881.
Targeting of antimicrobial agents by means of liposomes is under investigation and may be of importance in the treatment of infections that prove refractory to conventional forms of antimicrobial treatment. The ability to achieve a significantly longer residence time of liposomes in plasma and limited uptake of liposomes by the mononuclear phagocyte system opens up new areas of investigation and potential therapeutic application. By manipulating the liposomal composition, rates of uptake and intracellular degradation can be influenced and thereby the rates at which liposome-encapsulated agents are released and become available to exert their therapeutic action. With respect to the targeting of macrophage modulators at the mononuclear phagocyte system by means of liposomes for maximal stimulation of the nonspecific antimicrobial resistance, experimental evidence is now available of the potential usefulness of liposomes as carriers of these agents. This approach may also be of importance for the potentiation of treatment of severe infections.
利用脂质体靶向输送抗菌剂的研究正在进行中，这对于治疗那些对传统抗菌治疗无效的感染可能具有重要意义。脂质体在血浆中显著延长停留时间的能力以及单核吞噬细胞系统对脂质体的有限摄取，开辟了新的研究领域和潜在的治疗应用。通过控制脂质体的组成，可以影响摄取速率和细胞内降解速率，从而影响脂质体包裹药物的释放速率以及发挥治疗作用的可用速率。关于通过脂质体将巨噬细胞调节剂靶向输送至单核吞噬细胞系统以最大程度刺激非特异性抗菌抗性，现在已有实验证据表明脂质体作为这些药物载体具有潜在用途。这种方法对于增强严重感染的治疗效果也可能具有重要意义。
