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[儿童血管壁的纤维状蛋白质含量]

[Fibrillar protein content of the vascular wall of children].

作者信息

Drobkova I P, Aptekar' S G, Vikhert A M

出版信息

Arkh Patol. 1982;44(4):52-6.

PMID:7082200
Abstract

The content of fibrillar proteins was studied in 50 aortas of children dying at the age of 4 to 16 years of various diseases and accidents. In the intact intima of aortas the content of elastin and collagen increased with age. In lipid spots of the vascular wall of children the content of elastin was lower than in the intima, and the amount of collagen was higher than in the normal intima. In 15% of the aortas of children over 10 years of age lipid spots were found the content of collagen in which was above its average levels and biochemically reflected the development of collagen structures in lipid spots with destruction of lipid containing cells and release of lipids into the extracellular space. In rhythmical structures the content of fibrillar proteins increased as compared with normal intima irrespective of the age. The rhythmical structures with lipoidosis were intermediate with regard to the content of fibrillar proteins between "pure" rhythmical structures and lipid spots.

摘要

对50例死于4至16岁各种疾病和意外事故儿童的主动脉进行了纤维状蛋白含量的研究。在主动脉完整的内膜中,弹性蛋白和胶原蛋白的含量随年龄增长而增加。在儿童血管壁的脂质斑中,弹性蛋白的含量低于内膜,而胶原蛋白的含量高于正常内膜。在10岁以上儿童的主动脉中,15%发现了脂质斑,其中胶原蛋白含量高于平均水平,并且在生物化学上反映了脂质斑中胶原蛋白结构的发展,伴有含脂细胞的破坏和脂质释放到细胞外空间。在节律性结构中,无论年龄大小,纤维状蛋白的含量与正常内膜相比均增加。伴有类脂沉积的节律性结构在纤维状蛋白含量方面介于“单纯”节律性结构和脂质斑之间。

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