通过源自人淋巴细胞的可溶性介质增强系统性红斑狼疮中的自然杀伤细胞功能
Natural killer augmentation in systemic lupus erythematosus via a soluble mediator derived from human lymphocytes.
作者信息
Kaufman D B
出版信息
Arthritis Rheum. 1982 May;25(5):562-7. doi: 10.1002/art.1780250511.
Seventeen patients with diagnosed systemic lupus erythematosus were studied for natural killer activity and the ability of a human soluble immune-response factor to modify this activity. Defective natural killer activity was found in patients with systemic lupus erythematosus regardless of the stage of disease, medication, or organ system involvement (24.6% versus 47.8% cytotoxicity). After treatment with the immune-response factor, the natural killer activity increased in all patients, with a mean of 47.3% compared with 24.6% before treatment. This product has other immunologic activities and was shown to be free of interferon. The mechanism of action is not yet known, but such an immune-response factor has potential use in the treatment of systemic lupus erythematosus.
对17例确诊为系统性红斑狼疮的患者进行了自然杀伤活性以及人可溶性免疫反应因子改变这种活性能力的研究。发现系统性红斑狼疮患者无论疾病处于何阶段、使用何种药物或累及何种器官系统，其自然杀伤活性均存在缺陷（细胞毒性分别为24.6%和47.8%）。用免疫反应因子治疗后，所有患者的自然杀伤活性均升高，平均为47.3%，而治疗前为24.6%。该产品具有其他免疫活性，且已证明不含干扰素。其作用机制尚不清楚，但这种免疫反应因子在系统性红斑狼疮的治疗中具有潜在用途。
Zotero 插件