Oshimi K, Gonda N, Sumiya M, Kano S
Clin Exp Immunol. 1980 Apr;40(1):83-8.
The effects of corticosteroids on the natural killer (NK) cell activity of human peripheral blood lymphocytes were evaluated. When six untreated female patients with systemic lupus erythematosus were compared with fifteen age-matched, corticosteroid-treated female patients, NK activity in the latter was significantly suppressed. Although the administration of high doses seemed to suppress cytotoxicity to a greater extent, there was no close correlation between the daily doses of steroids and NK activity. When cytotoxicity levels were followed before and during corticosteroid therapy in the same patient, NK activity decreased markedly during treatment, particularly in patients on high-dose corticosteroids.
评估了皮质类固醇对人外周血淋巴细胞自然杀伤（NK）细胞活性的影响。将6名未经治疗的系统性红斑狼疮女性患者与15名年龄匹配、接受皮质类固醇治疗的女性患者进行比较，发现后者的NK活性明显受到抑制。尽管高剂量给药似乎在更大程度上抑制细胞毒性，但类固醇的每日剂量与NK活性之间没有密切相关性。当在同一患者的皮质类固醇治疗前和治疗期间跟踪细胞毒性水平时，治疗期间NK活性明显下降，尤其是在接受高剂量皮质类固醇治疗的患者中。
