Costa C, Angi M R, De Carli M, Vanzan S, Allegri G
Boll Soc Ital Biol Sper. 1982 Mar 30;58(6):333-9.
In order to clarify the role of tryptophan in the patogenesis of senile cataract, we have studied the serum total and free levels of tryptophan in cataract patients as compared with age and sex-matched controls, and the urinary excretion of 10 metabolites after oral load of the amino acid. This excretion increases in the cataract group both as total per cent and as kynurenine. No difference has been found in the free and total serum tryptophan between normal subjects and cataract patients. A possible role of the kynurenines in the pathogenesis of senile cataract is suggested.
为了阐明色氨酸在老年性白内障发病机制中的作用，我们研究了白内障患者血清中色氨酸的总水平和游离水平，并与年龄和性别匹配的对照组进行比较，同时还研究了口服该氨基酸后10种代谢产物的尿排泄情况。在白内障组中，这种排泄无论是作为总百分比还是作为犬尿氨酸都有所增加。正常受试者和白内障患者之间的血清游离色氨酸和总色氨酸没有差异。提示犬尿氨酸在老年性白内障发病机制中可能起作用。
