Merkur'eva R V, Litvinov N N, Aulika B V, Mukhambetova L Kh, Bushinskaia L I
Biull Eksp Biol Med. 1982 Apr;93(4):41-3.
The authors review the results of biochemical and cytological study of the function and enzymic structure of lung alveolar macrophages in the early stages of the development of the chemical carcinogen nitrosodimethylamine administered per os. The evidence obtained has shown that in the course of biological action of nitrosodimethylamine one can observe functional abnormalities of lung alveolar macrophages, accompanied by destabilization of the cell membrane and membranes of the subcellular organelles. This apparently reflects the manifestation of unfavourable action of the chemical carcinogen.
作者回顾了经口给予化学致癌物亚硝基二甲胺后，肺泡巨噬细胞功能和酶结构的生化及细胞学研究结果。所获得的证据表明，在亚硝基二甲胺的生物作用过程中，可以观察到肺泡巨噬细胞的功能异常，同时伴有细胞膜和亚细胞器膜的不稳定。这显然反映了化学致癌物的不良作用表现。
