[Effect of protein on the induction and renewal of a cytochrome P-450 complex in the rat liver].

It was disclosed that the effect on the content of cytochrome P450 and renewal of the protein portion of the cytochrome P450 complex in rat liver microsomes is determined by the protein amount in the diet. Protein deficiency in the diet leads to the reduced rate of protein fraction renewal in the cytochrome P450 complex. The degree of cytochrome P450 induction with phenobarbital was found to be dependent on the diet. In the animals fed low-protein diet (4.5%), the degree of cytochrome P450 induction was decreased which was likely to be a consequence of the increased semi-renewal period.