长春地辛单药化疗治疗非小细胞肺癌：45例报告
Vindesine (VDS) monochemotherapy for non-small cell lung cancer: a report of 45 cases.
作者信息
Luedke S L, Luedke D W, Petruska P, Broun G O, Reed G, Leavitt J
出版信息
Cancer Treat Rep. 1982 Jun;66(6):1409-11.
Fifty-three patients with non-small cell lung cancer were treated with vindesine. Of the 45 evaluable patients, 11 (24%) had a partial response. Responses were all evident within 6 weeks. Median duration of response was 8 weeks from documentation. Median survival was not improved significantly among responders (P less than 0.10, two-tailed test of significance). The most frequent toxic effect was leukopenia. The most troublesome toxic effect was peripheral neuropathy, with patients greater than 60 years old experiencing this more frequently.
53例非小细胞肺癌患者接受了长春地辛治疗。在45例可评估的患者中，11例（24%）出现部分缓解。缓解均在6周内显现。从记录之日起，缓解的中位持续时间为8周。缓解者的中位生存期无显著改善（P<0.10，双侧显著性检验）。最常见的毒性作用是白细胞减少。最棘手的毒性作用是周围神经病变，60岁以上的患者更常出现这种情况。
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