Parrilli G, Iaffaioli R V, Capuano G, Budillon G, Bianco A R
Cancer Treat Rep. 1982 Jun;66(6):1435-6.
Intestinal function during cytotoxic therapy was studied in nine patients with nonintestinal lymphoma. An early, marked, and rapidly reversible increase in passive permeability, as disclosed by the lactulose test, was observed without concomitant changes in active absorption or in intestinal histology. The possibility of a toxic effect by cytotoxic drugs on intestinal intracellular junctions is discussed.
对9例非肠道淋巴瘤患者在细胞毒性治疗期间的肠道功能进行了研究。通过乳果糖试验发现，被动通透性出现早期、显著且快速可逆的增加，而主动吸收或肠道组织学无相应变化。文中讨论了细胞毒性药物对肠道细胞间连接产生毒性作用的可能性。
