Hirsch S, Cháves G, Gotteland M, de la Maza P, Petermann M, Barrera P, Bunout D
Instituto de Nutrición y Tecnología de los Alimentos y Campus Central, Facultad de Medicina, Universidad de Chile.
Rev Med Chil. 1997 Jun;125(6):653-8.
Chronic alcoholism may increase intestinal permeability. However, there are few studies of intestinal permeability in chronic alcoholic subjects.
To study intestinal permeability in chronic alcoholic patients without clinical evidences of liver damage, during early abstinence, and in normal subjects.
Thirty seven male subjects were studied, 18 controls and 19 alcoholics. All subjects underwent an anthropometric assessment and dietary history. Lactulose/mannitol test was performed during the third day of abstinence in alcoholics. After an 8 hour overnight fast, subjects drank 200 ml of a solution containing 5 g lactulose and 5 g mannitol. Subsequently, urine was collected during the following 5 hours, where both sugars were measured by gas chromatography.
Median values of lactulose/mannitol ratio were similar in alcoholics and controls (0.011, range 0.005-0.071 vs 0.014, range 0.005-0.027 respectively). However, absolute urinary excretion of both lactulose and mannitol was lower in alcoholics. There was no relationship between nutritional status and urinary excretion of lactulose, mannitol or lactulose/mannitol ratio.
In these alcoholic patients, no changes were observed in intestinal permeability.
慢性酒精中毒可能会增加肠道通透性。然而，针对慢性酒精中毒患者肠道通透性的研究较少。
研究无肝脏损害临床证据的慢性酒精中毒患者在早期戒酒期间以及正常受试者的肠道通透性。
对37名男性受试者进行了研究，其中18名对照者和19名酗酒者。所有受试者均接受了人体测量评估和饮食史调查。酗酒者在戒酒第三天进行了乳果糖/甘露醇试验。经过8小时禁食过夜后，受试者饮用了200毫升含有5克乳果糖和5克甘露醇的溶液。随后，在接下来的5小时内收集尿液，通过气相色谱法测量两种糖的含量。
酗酒者和对照者的乳果糖/甘露醇比值中位数相似（分别为0.011，范围0.005 - 0.071和0.014，范围0.005 - 0.027）。然而，酗酒者中乳果糖和甘露醇的绝对尿排泄量较低。营养状况与乳果糖、甘露醇的尿排泄量或乳果糖/甘露醇比值之间没有关系。
在这些酒精中毒患者中，未观察到肠道通透性的变化。
