经氯法齐明处理的巨噬细胞培养物对125I标记免疫复合物的吞噬作用及细胞内降解
Phagocytosis and intracellular degradation of 125I-labelled immune complexes by Clofazimine treated macrophage cultures.
作者信息
Sarracent J, Finlay C M
出版信息
Clin Exp Immunol. 1982 Apr;48(1):268-72.
Abstract
Mouse peritoneal and calf alveolar macrophage cultures were exposed to various Clofazimine concentrations for 5 days. Cultures exposed to drug concentrations near the blood therapeutic level phagocytize and digest more immune complexes than control cultures. Our results allow us to suggest that the beneficial action of Clofazimine in lepromatous leprosy could be at least partially mediated by the removal and degradation of circulating immune complexes by macrophages.
摘要
将小鼠腹膜和小牛肺泡巨噬细胞培养物暴露于不同浓度的氯法齐明中5天。暴露于接近血液治疗水平药物浓度的培养物比对照培养物吞噬和消化更多的免疫复合物。我们的结果表明，氯法齐明在瘤型麻风病中的有益作用可能至少部分是由巨噬细胞清除和降解循环免疫复合物介导的。
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