人补体第一成分C1q亚成分B链N端108个氨基酸残基的氨基酸序列
Amino acid sequence of the N-terminal 108 amino acid residues of the B chain of subcomponent C1q of the first component of human complement.
作者信息
Reid K B, Thompson E O
出版信息
Biochem J. 1978 Sep 1;173(3):863-8. doi: 10.1042/bj1730863.
Abstract
The amino acid sequence of the N-terminal 108 residues of the B chain of subcomponent C1q of the first component of human complement was determined. The B chain has a blocked N-terminal amino acid, which was judged to be 5-oxopyrrolidine-2-carboxylic acid. A collagen-like region of 84 residues was found, which started at position B-6, and all of the six hydroxylysine residues and 12 hydroxyproline residues present in the chain were found in this region. Four of the six hydroxylysine residues may be glycosylated. The repeating nature of the collagen-like region is broken at position B-9, where alanine is found in a position where glycine would be expected. The exact position of the interchain disulphide bond joining the A and B chains of human subcomponent C1q was shown to be between residues A4 and B4.
摘要
已确定人补体第一成分C1q亚成分B链N端108个残基的氨基酸序列。B链的N端氨基酸被封闭，经判断为5-氧代吡咯烷-2-羧酸。发现了一个由84个残基组成的类胶原区域，该区域从B-6位开始，链中存在的六个羟赖氨酸残基和十二个羟脯氨酸残基均在该区域内。六个羟赖氨酸残基中的四个可能被糖基化。类胶原区域的重复性质在B-9位被打破，在预期为甘氨酸的位置发现了丙氨酸。已证明连接人C1q亚成分A链和B链的链间二硫键的确切位置在A4和B4残基之间。
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