人类补体第一成分C1q亚成分中存在的三个胶原样区域的完整氨基酸序列。
Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement.
作者信息
Reid K B
出版信息
Biochem J. 1979 May 1;179(2):367-71. doi: 10.1042/bj1790367.
Abstract
The sequences of amino acid residues 38--51 of the A-chain, and residues 42--90 of the C-chain, of human subcomponent C1q are given. These results, along with previously published sequence data [Reid (1974) Biochem.J. 141, 189--203; Reid (1977) Biochem.J. 161, 247--251; Reid & Thompson (1978) Biochem.J. 173, 863--868] allow the presentation, and comparison with each other, of the complete amino acid sequences of the collagen-like regions found in the A-, B- and C-chains of human subcomponent C1q. Each chain has the continuity of its collagen-like Gly-X-Y repeating triplet amino acid sequence broken. The B- and C-chains have alanine residues at positions B-9 and C-36 where glycine might be expected. The A-chain has a threonine residue at position A-39, which is located between two Gly-X-Y triplets.
摘要
给出了人补体C1q A链38 - 51位氨基酸残基以及C链42 - 90位氨基酸残基的序列。这些结果，连同先前发表的序列数据[里德（1974年）《生物化学杂志》141卷，189 - 203页；里德（1977年）《生物化学杂志》161卷，247 - 251页；里德和汤普森（1978年）《生物化学杂志》173卷，863 - 868页]，使得能够呈现人补体C1q A、B和C链中发现的胶原样区域的完整氨基酸序列，并相互比较。每条链的胶原样甘氨酸 - X - Y重复三联体氨基酸序列的连续性都被打破。B链和C链在预期为甘氨酸的B - 9位和C - 36位有丙氨酸残基。A链在位于两个甘氨酸 - X - Y三联体之间的A - 39位有一个苏氨酸残基。
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本文引用的文献
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A collagen-like amino acid sequence in a polypeptide chain of human C1q (a subcomponent of the first component of complement).人类C1q（补体第一成分的一个亚组分）多肽链中的一段类胶原蛋白氨基酸序列。
Biochem J. 1974 Jul;141(1):189-203. doi: 10.1042/bj1410189.
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Isolation and characterization of C1q, a subcomponent of the first component of complement, from human and rabbit sera.从人血清和兔血清中分离并鉴定补体第一成分的一个亚组分C1q。
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The chemistry and structure of collagen.胶原蛋白的化学性质与结构
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Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq).人补体成分C1q的超微结构（负染色-谷氨酰胺合成酶-生物活性C1q）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):65-8. doi: 10.1073/pnas.69.1.65.
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Subunit composition and structure of subcomponent C1q of the first component of human complement.人类补体第一成分C1q的亚基组成和结构
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Amino acid sequence of the N-terminal forty-two amino acid residues of the C chain of subcomponent C1q of the first component of human complement.人补体第一成分C1q亚成分C链N端42个氨基酸残基的氨基酸序列
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7
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Isolation, by partial pepsin digestion, of the three collagen-like regions present in subcomponent Clq of the first component of human complement.通过部分胃蛋白酶消化，从人补体第一成分C1q亚成分中分离出三个胶原样区域。
Biochem J. 1976 Apr 1;155(1):5-17. doi: 10.1042/bj1550005.
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