家畜和实验动物血清脂蛋白的密度分布及胆固醇浓度

The density profile and cholesterol concentration of serum lipoproteins in domestic and laboratory animals.

Terpstra A H, Sanchez-Muniz F J, West C E, Woodward C J

Comp Biochem Physiol B. 1982;71(4):669-73. doi: 10.1016/0305-0491(82)90479-5.

Abstract

By means of density gradient ultracentrifugation, the density profile of the serum lipoproteins was studied in 14 species of domestic and laboratory animals: the pig, chicken, rhesus monkey, rabbit, dog, horse, sheep, cat, mouse, goat, cow, guinea-pig, trout and rat. 2. The concentration of cholesterol in whole serum and the lipoprotein fractions of these animal species was also determined. 3. There were large differences in the density profile of the serum lipoproteins among the various animals studied and the results indicate that the density limits employed for human serum lipoproteins are not directly applicable to the lipoproteins of animals. 4. In most of the animals studied, three major lipoprotein fractions could be observed as in man. 5. However, such a clear pattern was not found in the cow, rat and guinea-pig. 6. In the animals studied, with the exception of the pig and the guinea-pig, most of the cholesterol in the serum was carried in the high density lipoprotein fraction.

摘要

通过密度梯度超速离心法，研究了14种家养和实验动物血清脂蛋白的密度分布，这些动物包括猪、鸡、恒河猴、兔、狗、马、羊、猫、小鼠、山羊、牛、豚鼠、鳟鱼和大鼠。2. 还测定了这些动物物种全血清及脂蛋白组分中的胆固醇浓度。3. 在所研究的不同动物中，血清脂蛋白的密度分布存在很大差异，结果表明用于人类血清脂蛋白的密度界限并不直接适用于动物脂蛋白。4. 在大多数所研究的动物中，可观察到与人类一样的三种主要脂蛋白组分。5. 然而，在牛、大鼠和豚鼠中未发现如此清晰的模式。6. 在除猪和豚鼠之外的所研究动物中，血清中的大部分胆固醇存在于高密度脂蛋白组分中。