Browne J L, Tsuang M T, Perry P J
Drug Intell Clin Pharm. 1982 May;16(5):404-7. doi: 10.1177/106002808201600509.
At this time, because of the lack of knowledge and experience in the treatment of amoxapine toxicity, it is impossible to formulate any conclusions concerning this drug's true toxic potential and capabilities. In toxic situations, amoxapine appears to produce some of the expected sequelae associated with TCAs. Neurotoxicity appears to be amoxapine's greatest toxic liability; the drug seems to have the ability to produce unusual neurological alterations, as well as a tendency to induce severe seizure activity. Procedures generally utilized for treatment of TCA or neuroleptic overdoses may prove inappropriate for dibenzoxazepine overdoses. It appears that intervention should include combating initiation of seizure activity and maintaining functional acid-base status. It has yet to be determined whether amoxapine or other dibenzoxazepine derivatives have a greater potential than other TCAs for inducing metabolic acidosis in toxic situations. However, observations from cases presented here would indicate this to be a distinct possibility.
目前，由于在阿莫沙平中毒治疗方面缺乏知识和经验，因此无法就该药物的真正毒性潜力和能力得出任何结论。在中毒情况下，阿莫沙平似乎会产生一些与三环类抗抑郁药相关的预期后遗症。神经毒性似乎是阿莫沙平最大的毒性负担；该药物似乎有能力产生异常的神经改变，以及诱发严重癫痫活动的倾向。通常用于治疗三环类抗抑郁药或抗精神病药过量的程序可能不适用于二苯并恶唑嗪过量。看来干预措施应包括对抗癫痫活动的发作并维持功能性酸碱状态。尚未确定阿莫沙平或其他二苯并恶唑嗪衍生物在中毒情况下比其他三环类抗抑郁药诱发代谢性酸中毒的可能性是否更大。然而，此处呈现的病例观察结果表明这是一种明显的可能性。
