嗜铬细胞瘤手术切除过程中血浆多巴胺-β-羟化酶和儿茶酚胺浓度的变化
Alterations in plasma dopamine-beta-hydroxylase and catecholamine concentrations during surgical removal of pheochromocytoma.
作者信息
Wocial B, Januszewicz W, Siedlecki I, Feltynowski T, Debiński W
出版信息
Endokrinologie. 1982 Feb;79(1):131-9.
In order to determine the mechanism of release of catecholamines from pheochromocytoma plasma levels of noradrenaline (NA), adrenaline (A), dopamine (DA) and dopamine-beta-hydroxylase (DBH) were measured in 6 patients with pheochromocytoma undergoing surgical treatment. In 4 patients both the DBH activity and plasma catecholamine concentrations rapidly increased during surgical manipulation of the tumor. In the remaining 2 patients dispite increase of plasma catecholamines DBH activity remained unchanged during surgical manipulation of the pheochromocytoma. The present results suggest that a certain fraction of plasma catecholamines in patients with pheochromocytoma is released from the tumor by exocytosis.
为了确定嗜铬细胞瘤释放儿茶酚胺的机制，对6例接受手术治疗的嗜铬细胞瘤患者测定了去甲肾上腺素（NA）、肾上腺素（A）、多巴胺（DA）和多巴胺-β-羟化酶（DBH）的血浆水平。在4例患者中，肿瘤手术操作期间DBH活性和血浆儿茶酚胺浓度均迅速升高。在其余2例患者中，尽管血浆儿茶酚胺增加，但嗜铬细胞瘤手术操作期间DBH活性保持不变。目前的结果表明，嗜铬细胞瘤患者血浆儿茶酚胺的一定比例是通过胞吐作用从肿瘤中释放出来的。
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