Maeda-Hagiwara M, Watanabe K
Eur J Pharmacol. 1982 Apr 8;79(1-2):105-10. doi: 10.1016/0014-2999(82)90580-5.
The gastric secretagogue action of ergot alkaloids was studied in the perfused stomach of anesthetized rats. Ergometrine dose-dependently increased gastric acid secretion and other ergot alkaloids, methysergide, methylergometrine, ergotamine and dihydroergotamine were also found to stimulate gastric secretion. However, Hydergine and bromocriptine did not influence the basal secretion. The gastric secretagogue action of ergometrine was completely inhibited by atropine and was markedly reduced but not abolished by vagotomy. Intraventricular administration of ergometrine produced an increase of acid secretion. Ergometrine did not affect the blood glucose level while insulin decreased it. The effect of ergometrine was not inhibited by serotonin agonistic or dopamine antagonistic agents. These results suggest that some ergot alkaloids have a gastric secretagogue action mainly due to their central effect in anesthetized rats and these actions cannot be explained by serotonin antagonistic, dopamine agonistic and alpha-adrenergic blocking effects of ergot alkaloids. The mechanism of the secretagogue action of ergometrine was different from that of insulin.
在麻醉大鼠的灌流胃中研究了麦角生物碱的促胃液分泌作用。麦角新碱剂量依赖性地增加胃酸分泌，并且还发现其他麦角生物碱，如美西麦角、甲基麦角新碱、麦角胺和双氢麦角胺也能刺激胃液分泌。然而，氢化麦角碱和溴隐亭不影响基础分泌。麦角新碱的促胃液分泌作用被阿托品完全抑制，迷走神经切断术可使其作用明显减弱但未消除。脑室内注射麦角新碱可使胃酸分泌增加。麦角新碱不影响血糖水平，而胰岛素可使其降低。麦角新碱的作用不受5-羟色胺激动剂或多巴胺拮抗剂的抑制。这些结果表明，某些麦角生物碱具有促胃液分泌作用，主要是由于其对麻醉大鼠的中枢作用，并且这些作用不能用麦角生物碱的5-羟色胺拮抗、多巴胺激动和α-肾上腺素能阻断作用来解释。麦角新碱促分泌作用的机制与胰岛素不同。
