多巴胺受体激动剂对麻醉大鼠灌流胃中经脑室注射促甲状腺激素释放激素诱导的胃酸分泌的影响。
Influence of dopamine receptor agonists on gastric acid secretion induced by intraventricular administration of thyrotropin-releasing hormone in the perfused stomach of anaesthetized rats.
作者信息
Maeda-Hagiwara M, Watanabe K
出版信息
Br J Pharmacol. 1983 May;79(1):297-303. doi: 10.1111/j.1476-5381.1983.tb10524.x.
Abstract
1 The influence of dopamine receptor agonists on gastric acid secretion stimulated by thyrotropin-releasing hormone (TRH) was studied in the perfused stomach of anaesthetized rats. 2 Intraventricular TRH produced a dose-dependent stimulation of basal gastric acid secretion. 3 Pretreatment with apomorphine, bromocriptine or methamphetamine inhibited the TRH-stimulated gastric acid secretion; these drugs did not influence bethanechol-induced acid secretion. 4 Haloperidol and metoclopramide prevented the antisecretory effects of apomorphine, bromocriptine and methamphetamine. 5 The present study suggests that central dopamine receptor stimulation inhibits intraventricular TRH-induced gastric acid secretion in rats.
摘要
1 在麻醉大鼠的灌流胃中研究了多巴胺受体激动剂对促甲状腺激素释放激素（TRH）刺激胃酸分泌的影响。2 脑室内注射TRH可产生剂量依赖性的基础胃酸分泌刺激作用。3 阿扑吗啡、溴隐亭或甲基苯丙胺预处理可抑制TRH刺激的胃酸分泌；这些药物不影响氨甲酰甲胆碱诱导的胃酸分泌。4 氟哌啶醇和甲氧氯普胺可阻断阿扑吗啡、溴隐亭和甲基苯丙胺的抗分泌作用。5 本研究提示，中枢多巴胺受体激动可抑制大鼠脑室内TRH诱导的胃酸分泌。
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Influence of dopamine receptor agonists on gastric acid secretion induced by intraventricular administration of thyrotropin-releasing hormone in the perfused stomach of anaesthetized rats.多巴胺受体激动剂对麻醉大鼠灌流胃中经脑室注射促甲状腺激素释放激素诱导的胃酸分泌的影响。
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引用本文的文献
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2
Intracerebroventricular injection of a TRH analogue, gamma-butyrolactone-gamma-carbonyl-L-histidyl-prolinamide, induces gastric lesions and gastric acid stimulation in rats.向大鼠脑室内注射促甲状腺激素释放激素类似物γ-丁内酯-γ-羰基-L-组氨酰-脯氨酰胺，会诱发胃部损伤并刺激胃酸分泌。
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本文引用的文献
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Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats.注射到大鼠下丘脑外侧的胃泌素会刺激胃酸分泌。
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Gastric secretagogue action of ergot alkaloids in the perfused stomach of anesthetized rats.麦角生物碱在麻醉大鼠灌流胃中的促胃液分泌作用。
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Possible involvement of nigrostriatal dopamine system in the inhibition of thyrotropin secretion in the rat.黑质纹状体多巴胺系统可能参与大鼠促甲状腺激素分泌的抑制过程。
Eur J Pharmacol. 1981 Dec 17;76(4):403-9. doi: 10.1016/0014-2999(81)90111-4.
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Endogenous opiates inhibit gastric acid secretion induced by central administration of thyrotropin-releasing hormone (TRH).内源性阿片肽抑制由促甲状腺激素释放激素（TRH）中枢给药诱导的胃酸分泌。
Life Sci. 1981 Jul 20;29(3):293-7. doi: 10.1016/0024-3205(81)90246-0.
8
Thyrotropin-releasing hormone--CNS action to stimulate gastric acid secretion.促甲状腺激素释放激素——刺激胃酸分泌的中枢神经系统作用。
Nature. 1980 Sep 11;287(5778):149-51. doi: 10.1038/287149a0.
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Thyrotropin releasing hormone (TRH) suppresses stress induced eating.促甲状腺激素释放激素（TRH）可抑制应激诱导的进食。
Life Sci. 1980 Jul 21;27(3):269-74. doi: 10.1016/0024-3205(80)90147-2.
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Central inhibition of basal pancreatic and gastric secretions by beta-endorphin in rats.大鼠中β-内啡肽对胰腺和胃基础分泌的中枢抑制作用。
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