氯贝丁酯对大鼠肝脏碱性磷酸酶和组氨酸-乙醛酸转氨酶的诱导作用。
Inducing effect of clofibrate on alkaline phosphatase and histidine-glyoxylate aminotransferase in rat liver.
作者信息
Panchenko L F, Popova S V, Antonenkov V D
出版信息
Experientia. 1982 Apr 15;38(4):433-4. doi: 10.1007/BF01952623.
PMID:7084402
Abstract
The activity of plasma membrane alkaline phosphatase and both mitochondrial and peroxisomal histidine-glyoxylate aminotransferase was significantly increased in the livers of male rats following treatment with the hypolipidemic drug clofibrate. Cycloheximide or puromycin administration to rats inhibited the effects of clofibrate.
摘要
用降血脂药物氯贝丁酯治疗雄性大鼠后，其肝细胞膜碱性磷酸酶以及线粒体和过氧化物酶体组氨酸-乙醛酸转氨酶的活性显著增加。给大鼠施用环己酰亚胺或嘌呤霉素可抑制氯贝丁酯的作用。
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