• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在受到辐射或注射5-氟尿嘧啶而对促红细胞生成素反应受损的小鼠中，缺氧期间促红细胞生成素的形成。

Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection.

作者信息

Barceló A C, Bozzini C E

出版信息

Experientia. 1982 Apr 15;38(4):504-5. doi: 10.1007/BF01952663.

DOI:10.1007/BF01952663
PMID:7084423
Abstract

Plasma erythropoietin levels during continuous exposure to hypobaric hypoxia in mice with marrow aplasia induced by whole body X-irradiation of 5-fluorouracil injection were higher than in control mice similarly exposed. There findings give support to the hypothesis that a relationship exists between erythropoietin production rate and erythroid responsiveness to the hormone.

摘要

在通过全身X射线照射或注射5-氟尿嘧啶诱导骨髓再生障碍的小鼠中，持续暴露于低压低氧环境时，其血浆促红细胞生成素水平高于同样暴露于该环境的对照小鼠。这些发现支持了促红细胞生成素产生率与红细胞系对该激素的反应性之间存在关联的假说。

相似文献

1
Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection.在受到辐射或注射5-氟尿嘧啶而对促红细胞生成素反应受损的小鼠中，缺氧期间促红细胞生成素的形成。
Experientia. 1982 Apr 15;38(4):504-5. doi: 10.1007/BF01952663.
2
Effect of erythropoietin on early recovery of erythropoiesis in mice after sublethal dose of 5-fluorouracil.促红细胞生成素对亚致死剂量5-氟尿嘧啶处理后小鼠红细胞生成早期恢复的影响。
Proc Soc Exp Biol Med. 1968 Jul;128(3):898-901. doi: 10.3181/00379727-128-33152.
3
Effects of human recombinant erythropoietin on differentiation and distribution of erythroid progenitor cells on murine medullary and splenic erythropoiesis during hypoxia and post-hypoxia.人重组促红细胞生成素对缺氧及缺氧后小鼠骨髓和脾脏红细胞生成过程中红系祖细胞分化和分布的影响。
In Vivo. 2001 Mar-Apr;15(2):125-32.
4
Enhanced hypoxia-stimulated erythropoietin production in mice with depression of erythropoiesis induced by hyperoxia.在因高氧导致红细胞生成受抑制的小鼠中，缺氧刺激促红细胞生成素产生增强。
High Alt Med Biol. 2003 Spring;4(1):73-9. doi: 10.1089/152702903321489004.
5
Comparison of erythropoietic response to erythropoietin-secreting stimuli in mice following polycythemia induced by transfusion or hypoxia.
Exp Hematol. 1985 Mar;13(3):159-62.
6
Comparison of radiation sensitivity, endogenous colony formation, and erythropoietin response following prolonged hypoxia exposure.长时间低氧暴露后辐射敏感性、内源性集落形成及促红细胞生成素反应的比较。
Radiat Res. 1969 Jun;38(3):530-43.
7
On the mechanism of erythropoietin-induced differentiation. XIV. The apparent effect of etiocholanolone on initiation of erythropoiesis.论促红细胞生成素诱导分化的机制。十四、表雄酮对红细胞生成起始的明显作用。
Exp Hematol. 1976 Jul;4(4):227-33.
8
Depression of stimulated erythropoietin production in mice with enhanced erythropoiesis.红细胞生成增强的小鼠中促红细胞生成素刺激产生的抑制作用。
Haematologica. 1995 Nov-Dec;80(6):491-4.
9
Isoproterenol induces amplification of the erythropoietin-responsive cell compartment.异丙肾上腺素可诱导促红细胞生成素反应性细胞区室的扩增。
Acta Physiol Lat Am. 1982;32(3):185-7.
10
Effect of hypoxia, irradiation, and bone marrow transplantation on erythropoietin levels in mice.缺氧、辐射及骨髓移植对小鼠促红细胞生成素水平的影响。
Radiat Res. 1970 Apr;42(1):151-63.

引用本文的文献

1
Effects of chemotherapeutic and immunosuppressive drugs on the production of erythropoietin in human hepatoma cultures.化疗药物和免疫抑制药物对人肝癌细胞培养中促红细胞生成素产生的影响。
Ann Hematol. 1993 Jan;66(1):27-31. doi: 10.1007/BF01737686.
2
Serum erythropoietin level: relationships to blood hemoglobin concentration and erythrocytic activity of the bone marrow.血清促红细胞生成素水平：与血血红蛋白浓度及骨髓红细胞生成活性的关系。
Klin Wochenschr. 1990 Apr 17;68(8):403-7. doi: 10.1007/BF01648581.

本文引用的文献

1
STIMULATION OF ERYTHROPOIETIN PRODUCTION BY WHOLE-BODY IRRADIATION (SPLEEN SHIELDED).
J Nucl Med. 1964 Aug;5:595-605.
2
Humoral regulation of erythropoiesis. V. Relationship of plasma erythropoietine level to bone marrow activity.红细胞生成的体液调节。五、血浆促红细胞生成素水平与骨髓活性的关系。
Proc Soc Exp Biol Med. 1959 Jan;100(1):40-3. doi: 10.3181/00379727-100-24516.
3
Studies on erythropoiesis. III. Factors controlling erythropoietin production.红细胞生成的研究。III. 控制促红细胞生成素产生的因素。
Proc Soc Exp Biol Med. 1957 Jan;94(1):237-41. doi: 10.3181/00379727-94-22910.
4
Influence of the erythroid activity of the bone marrow on the plasma disappearance of injected erythropoietin in dogs.
Nature. 1966 Mar 12;209(5028):1140-1. doi: 10.1038/2091140b0.
5
Erythropoietic activity of marrow and disappearance rate of erythropoietin in the rat.大鼠骨髓的红细胞生成活性及促红细胞生成素的消失率
Am J Physiol. 1969 Jul;217(1):297-301. doi: 10.1152/ajplegacy.1969.217.1.297.
6
Regulation of plasma erythropoietin levels in mice with impaired responsiveness to erythropoietin.对促红细胞生成素反应性受损的小鼠血浆促红细胞生成素水平的调节
J Lab Clin Med. 1971 Sep;78(3):449-56.
7
Production of and response to erythropoietin in the splenectomized mouse.脾切除小鼠中促红细胞生成素的产生及反应
Exp Hematol. 1976 Mar;4(2):114-20.
8
Measurement of erythropoiesis by radio-iron incorporation: influence of iron- and cell kinetic changes.通过放射性铁掺入法测量红细胞生成：铁和细胞动力学变化的影响
Exp Hematol. 1975 Jan;3(1):22-5.