Gross M, Goldwasser E
Exp Hematol. 1976 Jul;4(4):227-33.
Etiocholanolone, when tested in normal mice or in mice that have been out of an hypoxic atmosphere for only a few days, stimulates erythropoiesis, but appears to have no effect on erythropoiesis when tested in plethoric mice that have very low residual red cell formation. The steroid, similarly, stimulates hemoglobin synthesis by marrow cells in culture if they are from normal mice, but has no effect on cells from transfused mice. Out data suggest that 5 beta-H androstane and pregnane derivatives do not have a primary action on the induction of erythropoiesis, but act on cells that are already differentiated.
本胆烷醇酮在正常小鼠或仅脱离缺氧环境几天的小鼠中进行测试时，会刺激红细胞生成，但在红细胞生成极少的多血质小鼠中进行测试时，似乎对红细胞生成没有影响。同样，如果培养的骨髓细胞来自正常小鼠，该类固醇会刺激其血红蛋白合成，但对输血小鼠的细胞没有影响。我们的数据表明，5β-H雄甾烷和孕烷衍生物对红细胞生成的诱导没有主要作用，而是作用于已经分化的细胞。
