通过与大鼠单克隆IgG1相连实现对半抗原DNP的IgE反应的特异性免疫抑制。
Specific immunosuppression of IgE response to hapten DNP by linked to monoclonal IgG1 in rats.
作者信息
Pan D, Lee W Y, Shiao M S
出版信息
Experientia. 1982 Apr 15;38(4):508-9. doi: 10.1007/BF01952666.
PMID:7084424
Abstract
The induction of the anti-DNP IgE in rat was suppressed by pretreatment of rats with the tolerogen synthesized by coupling DNP to rat IgG, i.e.; DNP7-10-IgG. It was found that DNP10-IgG1 was an effective tolerogen, whereas other DNP conjugates, i.e. DNP9-IgM, DNP9-IgA, DNP10-IgE, DNP10-IgG2c and DNP10-IgG2a were ineffective.
摘要
用通过将二硝基苯（DNP）与大鼠免疫球蛋白G（IgG）偶联而合成的耐受原预处理大鼠，可抑制大鼠体内抗DNP IgE的诱导，即；DNP7 - 10 - IgG。发现DNP10 - IgG1是一种有效的耐受原，而其他DNP偶联物，即DNP9 - IgM、DNP9 - IgA、DNP10 - IgE、DNP10 - IgG2c和DNP10 - IgG2a则无效。
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