Balasch J, Vanrell J A, Márquez M, Burzaco I, González-Merlo J
Fertil Steril. 1982 Jun;37(6):751-4. doi: 10.1016/s0015-0282(16)46333-8.
Forty-four infertile patients with inadequate luteal phase histologically documented in at least two separate cycles and normal plasma levels of progesterone (P), estradiol (E2), and prolactin (PRL) were entered into treatment plans on a random basis involving at least 3 months of each of the following: P vaginal suppositories, dehydrogesterone, and no treatment. Success rates were similar for P (62.5%) and dehydrogesterone (68.7%), based on a corrected endometrial defect during the fourth treated cycle or when a term pregnancy was achieved. However, these figures are significantly different (P less than 0.001) when compared with 16.6% of the control group. In ten additional infertile patients with normal luteal function as assessed by endometrial histologic study and hormone measurements, a second biopsy was performed in a consecutive cycle under dehydrogesterone administration. In no case was the normal secretory pattern impaired. It is concluded that (1) both P and dehydrogesterone can be used to advantage in the treatment of luteal phase defects, and (2) therapy with dehydrogesterone does not alter the normal pattern of endometrial secretion.
44例黄体期不足的不孕患者，经组织学证实至少在两个不同周期存在该情况，且血浆孕酮（P）、雌二醇（E2）和催乳素（PRL）水平正常，被随机纳入治疗方案，每个方案至少持续3个月，分别为：阴道用P栓剂、地屈孕酮以及不治疗。基于第四个治疗周期时子宫内膜缺陷得到纠正或实现足月妊娠，P（62.5%）和地屈孕酮（68.7%）的成功率相似。然而，与对照组的16.6%相比，这些数字有显著差异（P小于0.001）。另外10例经子宫内膜组织学研究和激素测量评估黄体功能正常的不孕患者，在连续周期接受地屈孕酮治疗时进行了第二次活检。在任何情况下，正常分泌模式均未受损。结论为：（1）P和地屈孕酮均可有效用于治疗黄体期缺陷；（2）地屈孕酮治疗不会改变子宫内膜分泌的正常模式。
