Chang S Y, Soong Y K, Chang M Y, Hsiu D Y
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
J In Vitro Fert Embryo Transf. 1989 Oct;6(5):275-9. doi: 10.1007/BF01139181.
Exogenous progesterone (P) was supplemented to gamete intrafallopian transfer (GIFT) patients to determine the optimal timing to start P supplementation and the role of isthmic block in GIFT. Patients were alternatively divided into two groups. In the immediate group, exogenous P was supplied from the day of surgery. In the delayed group, P was supplied 4 days after the surgery, the day the fertilized ovum is supposed to arrive in the uterine cavity. Except for higher serum P levels on luteal day 3 in the immediate group, no significant differences were found in serum P levels during the early luteal phase, the pregnancy rate, and the abortion rate between the two groups. It is possible that in stimulated cycles, higher serum P levels during the early luteal phase render the endometrium receptive for embryo implantation, albeit unlock the isthmic block. It may not be crucial to start exogenous P supplementation either before or after a fertilized egg(s) arrives in the uterine cavity. The role of isthmic block in GIFT needs further evaluation.
对配子输卵管内移植（GIFT）患者补充外源性孕酮（P），以确定开始补充P的最佳时机以及峡部阻塞在GIFT中的作用。患者被交替分为两组。在即刻组中，从手术当天开始补充外源性P。在延迟组中，在手术后4天，即受精卵预计到达子宫腔的当天补充P。除了即刻组在黄体期第3天血清P水平较高外，两组在黄体早期血清P水平、妊娠率和流产率方面均未发现显著差异。在促排卵周期中，黄体早期较高的血清P水平可能使子宫内膜易于接受胚胎着床，尽管这会解除峡部阻塞。在受精卵到达子宫腔之前或之后开始补充外源性P可能并不关键。峡部阻塞在GIFT中的作用需要进一步评估。
