Satoh H, Guth P H, Grossman M I
Gastroenterology. 1982 Jul;83(1 Pt 2):210-5.
This study was undertaken to determine the role of food in indomethacin-induced gastrointestinal lesions. Following a 24- or 48- fast, rats were given various amounts of rat Chow pellets or various types of diets (high-bulk non-nutritive diet, equicaloric liquid diet, or liquid diet containing cellulose) for 1 h. One half hour after the feeding, 30 mg/kg of indomethacin was administered subcutaneously, and 6 h later the animals were killed and gastrointestinal lesions measured. In the fasted rat, indomethacin produced lesions predominantly in the gastric corpus. In the rat that was fed Chow pellets, indomethacin produced lesions in both the gastric antrum and small intestine. By increasing food intake, the corpus lesions decreased while antral and intestinal lesions increased. In the rat that was fed cellulose or sawdust pellets, indomethacin produced lesions in all three areas. In contrast, indomethacin did not produce any lesions in the liquid diet group. However, when cellulose was added to the liquid diet, indomethacin produced lesions in both the antrum and small intestine, the lesions increasing in proportion to increasing concentrations of cellulose. It is concluded that in indomethacin-induced gastrointestinal lesions: (a) the nutritional component of food prevents the formation of corpus lesions, and (b) the solid component of food, whether nutritive or not, plays an essential role in the formation of antral and intestinal lesions.
本研究旨在确定食物在吲哚美辛诱导的胃肠道损伤中的作用。禁食24或48小时后，给大鼠喂食不同量的大鼠饲料颗粒或不同类型的日粮（高容积无营养日粮、等热量液体日粮或含纤维素的液体日粮）1小时。喂食后半小时，皮下注射30mg/kg吲哚美辛，6小时后处死动物并测量胃肠道损伤情况。在禁食的大鼠中，吲哚美辛主要在胃体产生损伤。在喂食饲料颗粒的大鼠中，吲哚美辛在胃窦和小肠均产生损伤。通过增加食物摄入量，胃体损伤减少，而胃窦和小肠损伤增加。在喂食纤维素或木屑颗粒的大鼠中，吲哚美辛在所有三个区域均产生损伤。相比之下，吲哚美辛在液体日粮组未产生任何损伤。然而，当向液体日粮中添加纤维素时，吲哚美辛在胃窦和小肠均产生损伤，损伤程度随纤维素浓度增加而增加。得出结论：在吲哚美辛诱导的胃肠道损伤中：（a）食物的营养成分可防止胃体损伤的形成，（b）食物的固体成分，无论有无营养，在胃窦和小肠损伤的形成中起重要作用。
