Carlquist M, Jörnvall H, Tatemoto K, Mutt V
Gastroenterology. 1982 Jul;83(1 Pt 2):245-9.
The polypeptide known as the "vasoactive intestinal polypeptide" has now been isolated from porcine brain. Determination of the structure shows that cerebral vasoactive intestinal polypeptide consists of 28 amino acid residues in the sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys -Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2. This structure is identical to that of vasoactive intestinal polypeptide previously isolated from porcine and bovine upper intestine, and its amino acid composition is identical to that of human vasoactive intestinal polypeptide from colon. Although immunoreactive vasoactive intestinal polypeptide has been shown previously to be present in different tissues, this is the first time it has actually been isolated from cerebral tissue, or indeed from any nonintestinal tissue.
现在已经从猪脑中分离出了被称为“血管活性肠肽”的多肽。其结构测定表明，脑源性血管活性肠肽由28个氨基酸残基组成，序列为：组氨酸-丝氨酸-天冬氨酸-丙氨酸-缬氨酸-苯丙氨酸-苏氨酸-天冬氨酸-天冬酰胺-酪氨酸-苏氨酸-精氨酸-亮氨酸-精氨酸-赖氨酸-谷氨酰胺-甲硫氨酸-丙氨酸-缬氨酸-赖氨酸-赖氨酸-酪氨酸-亮氨酸-天冬酰胺-丝氨酸-异亮氨酸-亮氨酸-天冬酰胺-氨基。该结构与先前从猪和牛的上肠道中分离出的血管活性肠肽的结构相同，其氨基酸组成与来自结肠的人血管活性肠肽的氨基酸组成相同。尽管先前已证明免疫活性血管活性肠肽存在于不同组织中，但这是首次实际从脑组织或任何非肠道组织中分离出它。
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