Kalimi M, Banerji A
Gerontology. 1982;28(2):91-8. doi: 10.1159/000212516.
Specific in vitro glucocorticoid uptake and binding activity of spleen and splenic leukocytes were examined in adult (2- to 3-month-old) and senescent (24- to 28-month-old) male, adrenalectomized Sprague-Dawley and Wistar rats. No significant differences in these parameters were evident between young and old animals of either strain. Moreover, cortisol inhibition of [5-3H]-uridine uptake and the total number of glucocorticoid binding sites of spleen and its leukocytes were found to be similar in these two age groups. It was concluded that age has no effect on the glucocorticoid responsiveness of the splenic tissues of the two strains of male rats studied.
在成年（2至3月龄）和衰老（24至28月龄）的雄性、肾上腺切除的斯普拉格-道利大鼠和Wistar大鼠中，检测了脾脏及其白细胞的特异性体外糖皮质激素摄取和结合活性。在这两个品系的年轻和老年动物之间，这些参数没有明显差异。此外，发现在这两个年龄组中，皮质醇对[5-3H]-尿苷摄取的抑制作用以及脾脏及其白细胞的糖皮质激素结合位点总数相似。得出的结论是，年龄对所研究的两种品系雄性大鼠脾脏组织的糖皮质激素反应性没有影响。
