Rohen J W
Graefes Arch Clin Exp Ophthalmol. 1982;218(4):171-6. doi: 10.1007/BF02150090.
In the last few years matrix vesicles (M.V.) have been found in the vessel wall in various diseases and are considered to be related with pathological changes of the extracellular fibers of the tissue (atypical collagen etc.). Since the trabecular meshwork, at least the cribriform region, may be looked upon as a part of a vessel wall, it was an obvious conclusion to look for M.V. even in this area. Lysosomal and non-lysosomal M.V. were found in 138 trabeculectomy-specimens of various kinds of glaucoma, located for the most part within the cribriform or juxta-canalicular region of the meshwork. In ten cases small, electron-dense M.V. were found which ultrahistochemically showed a positive reaction for acid phosphatase. This proves that these vesicles are indeed extracellular lysosomes.
在过去几年中，已在各种疾病的血管壁中发现基质小泡（M.V.），并认为其与组织细胞外纤维（非典型胶原蛋白等）的病理变化有关。由于小梁网，至少是筛状区域，可被视为血管壁的一部分，因此在该区域寻找M.V.是一个显而易见的结论。在各种青光眼的138个小梁切除术标本中发现了溶酶体和非溶酶体M.V.，它们大多位于小梁网的筛状或近小管区域内。在10例病例中发现了小的、电子致密的M.V.，超组织化学显示其对酸性磷酸酶呈阳性反应。这证明这些小泡确实是细胞外溶酶体。
