Staubesand J, Fischer N
Connect Tissue Res. 1980;7(4):213-7. doi: 10.3109/03008208009152356.
Quite unrelated diseases affecting different organs can lead to the appearance of abnormal collagen fibrils, which may be due to genetic disorders, transformation of mesenchyme cells, increased collagen synthesis or a change in the ground-substance. The simultaneous appearance of abnormal collagen fibrils and matrix vesicles containing lysosomal enzymes in the majority of our electron photomicrographs suggests an alteration in the ground-substance as a main cause of non-hereditary collagen dysplasia.
影响不同器官的完全不相关的疾病可导致异常胶原纤维的出现，这可能是由于遗传疾病、间充质细胞转化、胶原合成增加或基质改变所致。在我们大多数电子显微镜照片中，异常胶原纤维和含有溶酶体酶的基质小泡同时出现，这表明基质改变是非遗传性胶原发育异常的主要原因。
