Simpson C F
Atherosclerosis. 1978 Aug;30(4):249-54. doi: 10.1016/0021-9150(78)90117-x.
Hypertensive and hypotensive lines of turkeys were treated with diethylstilbestrol (DES) alone, or with DES and propranolol (PROP). Untreated turkeys of each blood pressure line served as controls. Mortality rate from aortic ruptures was highest (43.7%) in the hypertensive line treated with DES, but mortality was reduced to 7.7% when this line of turkey was treated with both DES and PROP. Among the hypotensive line of turkeys treated with DES, 26.7% died of aortic ruptures, but none died when these turkeys were treated with DES and PROP. Propranolol did not influence serum cholesterol levels, and all DES or DES and PROP treated birds had greatly elevated values, as contrasted to untreated turkeys. Aortic lipid values were highest in the hypotensive line of turkeys treated with DES, but, by histologic evaluation, aortic atherosclerosis was equally severe in all DES-treated turkeys. Blood pressure and aortic dp/dt max were higher in the hypertensive line treated with DES than in the similarly treated hypotensive line. This probably accounted for the higher mortality in the former group. Absence of significant mortality in either line of turkey following treatment with both DES and PROP apparently resulted from the decreased stress on the aorta caused by lowering of blood pressure and aortic dp/dt max by PROP.
对高血压品系和低血压品系的火鸡分别单独使用己烯雌酚（DES）进行处理，或同时使用己烯雌酚和普萘洛尔（PROP）进行处理。每个血压品系未处理的火鸡作为对照。在使用DES处理的高血压品系中，主动脉破裂导致的死亡率最高（43.7%），但当该品系火鸡同时使用DES和PROP进行处理时，死亡率降至7.7%。在使用DES处理的低血压品系火鸡中，26.7%死于主动脉破裂，但当这些火鸡同时使用DES和PROP进行处理时，无一只死亡。普萘洛尔不影响血清胆固醇水平，与未处理的火鸡相比，所有使用DES或同时使用DES和PROP处理的禽类血清胆固醇水平都大幅升高。在使用DES处理的低血压品系火鸡中，主动脉脂质值最高，但通过组织学评估，所有使用DES处理的火鸡主动脉粥样硬化程度相同。使用DES处理的高血压品系火鸡的血压和主动脉dp/dt max高于同样处理的低血压品系火鸡。这可能是前一组死亡率较高的原因。在同时使用DES和PROP处理后，两个品系的火鸡均未出现显著死亡率，这显然是由于PROP降低了血压和主动脉dp/dt max，从而减轻了主动脉的压力。
