Schill W B
Fortschr Med. 1982 Apr 22;100(15):696-700.
25 men with idiopathic asthenozoospermia and 40 men with idiopathic normogonadotropic oligozoospermia were treated for three months by systemic pentoxifylline administration (1,2 g per day orally). In the asthenozoospermia group a statistically significant increase of progressive sperm motility was observed. Conception rate within the asthenozoospermic group was calculated to be 37%. In the oligozoospermic group semen parameters were not affected. There was only a small transitory increase of the ejaculate volumen an seminal plasma fructose level. The conception rate within this group of oligozoospermic men was calculated to be 17%. As mode of action of systemic pentoxifylline treatment an improvement of the microcirculation within the epididymis and the male accessory sexual glands is discussed which may lead to an improved epididymal sperm maturation and an amelioration of the biochemical composition of the secretions of the male accessory sexual glands.
25名特发性弱精子症男性和40名特发性正常促性腺激素性少精子症男性接受了为期三个月的己酮可可碱全身给药治疗（每天口服1.2克）。在弱精子症组中，观察到进行性精子活力有统计学意义的增加。弱精子症组的受孕率经计算为37%。在少精子症组中，精液参数未受影响。仅射精量和精浆果糖水平有小幅短暂升高。该组少精子症男性的受孕率经计算为17%。关于己酮可可碱全身治疗的作用方式，讨论了其对附睾和男性附属性腺微循环的改善，这可能导致附睾精子成熟的改善以及男性附属性腺分泌物生化组成的改善。
