是否有可能预测减敏治疗的临床效果？
Is is possible to predict the clinical effect of hyposensitization?
作者信息
Osterballe O, Løwenstein H, Malling H J, Petersen B N, Weeke B
出版信息
Int Arch Allergy Appl Immunol. 1982;68(3):286-8. doi: 10.1159/000233114.
Sera from 73 grass pollen allergic patients in two double blind studies on hyposensitization were investigated for IgE response towards one major timothy allergen-antigen 19 (Ag 19) by means of crossed radioimmunoelectrophoresis (CRIE). The clinical efficacy of hyposensitization after initial preseasonal treatment was positively correlated with increase in specific IgE binding to Ag 19. It was possible to predict the clinical efficacy by comparing CRIE performed on sera before and after 3 months of treatment.
在两项关于减敏疗法的双盲研究中，对73名草花粉过敏患者的血清进行了研究，通过交叉放射免疫电泳（CRIE）检测其针对一种主要梯牧草过敏原——抗原19（Ag 19）的IgE反应。初始季前治疗后减敏疗法的临床疗效与特异性IgE与Ag 19结合的增加呈正相关。通过比较治疗3个月前后血清的CRIE结果，可以预测临床疗效。
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