Nordvall S L, Renck B, Einarsson R
Department of Paediatrics, St. Göran's Children's Hospital, Stockholm, Sweden.
Allergy. 1989 Aug;44(6):380-4. doi: 10.1111/j.1398-9995.1989.tb04168.x.
Fourteen children with timothy grass pollinosis were given immunotherapy (IT) for 3 years with a purified and characterized timothy grass pollen preparation or a crude aqueous timothy pollen extract. Crossed radioimmunoelectrophoresis (CRIE) showed that 75% of the children under 11 years of age developed new specificities of IgE antibodies against timothy antigens, in contrast to older children, where no development of IgE antibodies against new timothy antigens could be detected. IgE antibodies were only detected against antigens formerly known as allergens. Timothy-specific IgG antibodies increased in most children during hyposensitization against the major allergens Ag 19 and Ag 24/25 and several other IgE-binding timothy antigens.
14名患有梯牧草花粉症的儿童接受了3年的免疫疗法（IT），使用的是纯化并经过特性鉴定的梯牧草花粉制剂或粗制梯牧草花粉水提取物。交叉放射免疫电泳（CRIE）显示，11岁以下的儿童中有75%产生了针对梯牧草抗原的IgE抗体新特异性，相比之下，年龄较大的儿童未检测到针对新梯牧草抗原的IgE抗体产生。仅检测到针对以前已知为过敏原的抗原的IgE抗体。在针对主要过敏原Ag 19和Ag 24/25以及其他几种与IgE结合的梯牧草抗原进行减敏治疗期间，大多数儿童的梯牧草特异性IgG抗体增加。
