Frostad A B, Grimmer O, Sandvik L, Moxnes A, Aas K
Clin Allergy. 1983 Jul;13(4):337-57. doi: 10.1111/j.1365-2222.1983.tb02609.x.
Most extracts used in hyposensitization are complex and ill-defined mixtures of a large number of antigenic components. A highly refined (purified) and well-characterized allergen preparation from Timothy pollen (Phleum pratense) is now available. This paper describes the results of hyposensitization for 3 years comparing the purified preparation Timothy N, the crude extract Timothy O and a four-grass mix in sixty patients with allergic rhinitis due to grass pollen. The sixty patients were randomized into three groups and compared with a control group not hyposensitized. All three groups showed a significant decrease in clinical symptoms compared with the control group. The Timothy N group had a significantly higher nasal tolerance shown by nasal challenge test after 3 years' treatment than the group treated with the crude extract (P = 0.05). In addition, the Timothy-N-treated patients needed significantly less antihistaminic medication than the patients having received the crude extract or the four-grass mix (P = 0.02 and P = 0.01, respectively).
大多数用于减敏治疗的提取物都是复杂且成分不明的混合物，含有大量抗原成分。现在已有一种高度精制（纯化）且特性明确的来自梯牧草花粉（早熟禾）的变应原制剂。本文描述了对60例因草花粉引起变应性鼻炎的患者进行为期3年的减敏治疗结果，比较了纯化制剂梯牧草N、粗提取物梯牧草O和四草混合制剂。这60例患者被随机分为三组，并与未进行减敏治疗的对照组进行比较。与对照组相比，所有三组的临床症状均有显著减轻。经过3年治疗后，梯牧草N组经鼻激发试验显示出的鼻耐受性显著高于接受粗提取物治疗的组（P = 0.05）。此外，接受梯牧草N治疗的患者所需的抗组胺药物明显少于接受粗提取物或四草混合制剂治疗的患者（分别为P = 0.02和P = 0.01）。
