Arad I D, Sagi E, Eyal F G
Int J Vitam Nutr Res. 1982;52(1):50-4.
During gestation the fetus is abundantly provided with vitamin C, but inadequate postnatal provision of the vitamin may lead to early hypoascorbemia. Since premature newborns are often prevented from full alimentation for a considerable length of time, ascorbate deficiency may result. Plasma ascorbate levels of 20 premature newborns were determined during the first two weeks of life. Daily ascorbate intake of less than 5 mg/kg b. w. resulted in a decline of plasma ascorbate level from 1.56 +/- 0.15 mg/100 ml (mean +/- SEM) on the first day of life to a low level of 0.48 +/- 0.05 mg/100 ml by two weeks of age. An increase of daily ascorbate intake to 5--10 mg/kg b.w. resulted in a higher plasma concentration of 0.79 +/- 0.09 mg/100 ml (p less than 0.02) while parenteral supplementation of 50 mg vitamin C daily provided for a high plasma concentration of 2.7 +/- 0.46 mg/100 ml (p less than 0.005) when compared with the other two groups. Maturational and environmental factors may impose a higher demand for vitamin C during early premature life and therefore adequate amounts of the vitamin should be early provided.
在孕期，胎儿会获得充足的维生素C，但出生后维生素供应不足可能导致早期低血维生素C症。由于早产儿往往在相当长一段时间内无法完全正常进食，可能会导致抗坏血酸缺乏。测定了20名早产儿出生后前两周的血浆抗坏血酸水平。每日抗坏血酸摄入量低于5毫克/千克体重，导致血浆抗坏血酸水平从出生第一天的1.56±0.15毫克/100毫升（平均值±标准误）下降到两周龄时的低水平0.48±0.05毫克/100毫升。每日抗坏血酸摄入量增加到5 - 10毫克/千克体重，血浆浓度升高至0.79±0.09毫克/100毫升（p<0.02），而每日静脉补充50毫克维生素C，与其他两组相比，血浆浓度高达2.7±0.46毫克/100毫升（p<0.005）。成熟和环境因素可能使早产早期对维生素C的需求更高，因此应尽早提供足够量的该维生素。
