Zielinski A, Brenner T, Abramsky O
Isr J Med Sci. 1982 Apr;18(4):483-6.
A group of myasthenia gravis (MG) patients was studied in order to demonstrate the differential ability of acetylcholine receptor (AChR) antibodies to bind to AChRs from different sources. Four different AChR sources were used: human muscle, denervated rat muscle, normal rat muscle and the electric organ of the electric ray, Torpedo californica. We demonstrated that AchR antibodies from MG patients tested reacted best with receptors from human muscle, and least with the electric ray receptor. The patients were classified into three categories, each representing an antibody level pattern. THe most common pattern was that in which the antibody level for human AchR is highest, followed by decreasing values for AchRs of denervated rat muscle, normal rat muscle, and that of the electric organ of the electric ray. No correlation was found between the patient-specific antibody pattern and a clinical description of the MG patient.
为了证明乙酰胆碱受体（AChR）抗体与不同来源的AChR结合的差异能力，对一组重症肌无力（MG）患者进行了研究。使用了四种不同的AChR来源：人肌肉、去神经支配的大鼠肌肉、正常大鼠肌肉以及电鳐（加州电鳐）的电器官。我们证明，所检测的MG患者的AChR抗体与人肌肉中的受体反应最佳，与电鳐受体反应最差。患者被分为三类，每类代表一种抗体水平模式。最常见的模式是，人AChR的抗体水平最高，其次是去神经支配的大鼠肌肉、正常大鼠肌肉以及电鳐电器官的AChR抗体水平逐渐降低。未发现患者特异性抗体模式与MG患者的临床描述之间存在相关性。
