Lindstrom J, Campbell M, Nave B
Muscle Nerve. 1978 Mar-Apr;1(2):140-5. doi: 10.1002/mus.880010206.
Antisera to acetylcholine receptor purified from the electric organs of Torpedo and Electrophorus were highly species specific, but showed limited cross-reaction with receptors from all mammalian species tested. Antisera to receptor purified from rat muscle cross-reacted extensively with receptor from the muscles of other mammals. Antibodies to receptor from Electrophorus cross-reacting with receptor from Torpedo were affinity purified. Subsequently these showed increased cross-reaction with receptor from mammalian muscle. Sera from patients with myasthenia gravis reacted best with receptor from human muscle, but such sera also cross-reacted with receptor from other mammals, especially squirrel monkeys. These sera cross-reacted slightly with receptor from Torpedo, but not detectably with receptor from Electrophorus,
从电鳐和电鳗的电器官中纯化得到的抗乙酰胆碱受体抗血清具有高度的物种特异性，但与所有测试的哺乳动物物种的受体显示出有限的交叉反应。从大鼠肌肉中纯化得到的受体抗血清与其他哺乳动物肌肉中的受体有广泛的交叉反应。与电鳐受体发生交叉反应的电鳗受体抗体经过亲和纯化。随后，这些抗体与哺乳动物肌肉中的受体的交叉反应增加。重症肌无力患者的血清与人类肌肉中的受体反应最佳，但此类血清也与其他哺乳动物的受体发生交叉反应，尤其是松鼠猴的受体。这些血清与电鳐的受体有轻微交叉反应，但与电鳗的受体无明显交叉反应。
