[Budd-Chiari syndrome in DTIC therapy].

A 41-year-old female patient with malignant melanoma developed a sudden hepatic vein thrombosis (Budd-Chiarisyndrome) followed by rapid deterioration and death after treatment with DTIC (dacarbazine). The event occurred after the second injection during the second therapeutic cycle and was paralleled by an increase of the number of blood eosinophils. As described before increasing blood eosinophilia appears to be a sign of imminent DTIC-complication of this type.